Tight Junction Proteins and the Biology of Hepatobiliary Disease. - Institut de recherche sur les maladies virales et hépatiques
Article Dans Une Revue International Journal of Molecular Sciences Année : 2020

Tight Junction Proteins and the Biology of Hepatobiliary Disease.

Résumé

Tight junctions (TJ) are intercellular adhesion complexes on epithelial cells and composed of integral membrane proteins as well as cytosolic adaptor proteins. Tight junction proteins have been recognized to play a key role in health and disease. In the liver, TJ proteins have several functions: they contribute as gatekeepers for paracellular diffusion between adherent hepatocytes or cholangiocytes to shape the blood-biliary barrier (BBIB) and maintain tissue homeostasis. At non-junctional localizations, TJ proteins are involved in key regulatory cell functions such as differentiation, proliferation, and migration by recruiting signaling proteins in response to extracellular stimuli. Moreover, TJ proteins are hepatocyte entry factors for the hepatitis C virus (HCV)-a major cause of liver disease and cancer worldwide. Perturbation of TJ protein expression has been reported in chronic HCV infection, cholestatic liver diseases as well as hepatobiliary carcinoma. Here we review the physiological function of TJ proteins in the liver and their implications in hepatobiliary diseases.
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hal-02917277 , version 1 (11-09-2024)

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Natascha Roehlen, Armando Andres Roca Suarez, Houssein El Saghire, Antonio Saviano, Catherine Schuster, et al.. Tight Junction Proteins and the Biology of Hepatobiliary Disease.. International Journal of Molecular Sciences, 2020, 21 (3), ⟨10.3390/ijms21030825⟩. ⟨hal-02917277⟩
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